|
KMID : 0378019750180020145
|
|
New Medical Journal
1975 Volume.18 No. 2 p.145 ~ p.152
|
|
|
A Study on the Cytotoxic Effects of the Toxic Fungal Metabolites from Korean Foodstuffs on HeLa Cells
|
|
|
|
|
Abstract
|
|
|
The culture filtrates of twenty-four fungal strains isolated from diverse sources in Korean foods-were tested for detection of mycotoxin-producing fungi and toxic effects produced in HeLa cells. The results are summarized as follows:
1. Fifteen strains(62.5%) were toxic to HeLa cells.
2. Among these, 4 isolates(16.7%) were shown to be markedly, 5 (20.8%) moderately, 6 (25. 0%) slightly and 9 (37.5%) not toxic to HeLa cells.
3. The effects of the culture filtrates on HeLa cells involved morphological changes such as granulation and clumping, accumulation of mitotic cells, appearance of polynuclear cells and mitotic figures possibly arrested at metaphase. Consequent atypism of HeLa cells was often seen.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|